Kurwanya abantu IGFBP-1 Antibody, Imbeba Monoclonal
Ibisobanuro birambuye
Amakuru rusange
IGFBP1, izwi kandi nka IGFBP-1 hamwe na insuline imeze nkikura-ihuza poroteyine 1, ni umwe mu bagize umuryango wa insuline umeze nk’imikurire ihuza umuryango wa poroteyine.IGF ihuza poroteyine (IGFBPs) ni poroteyine za 24 kugeza 45 kDa.IGFBPs zose uko ari esheshatu zisangiye 50% homology kandi zifite aho zihurira na IGF-I na IGF-II muburyo bumwe nkubunini bwa ligande kuri IGF-IR.Intungamubiri za poroteyine za IGF zongerera igice cya kabiri cyubuzima bwa IGF kandi byagaragaye ko zibuza cyangwa zitera ingaruka ziterambere ry’iterambere rya IGF ku muco w’akagari.Bahindura imikoranire ya IGFs hamwe na selile yakira.IGFBP1 ifite indangarugero ya IGFBP hamwe na thyroglobulin ubwoko-I.Ihuza ibintu byombi bikura nka insuline (IGFs) I na II kandi bizenguruka muri plasma.Guhuza iyi poroteyine byongerera igice cya kabiri cyubuzima bwa IGFs kandi bigahindura imikoranire yabyo hamwe nubutaka bwakirwa.
Ibyiza
| Icyifuzo | CLIA (Gufata-Kumenya): 4H6-2 ~ 4C2-3 4H6-2 ~ 2H11-1 |
| Isuku | > 95% nkuko byagenwe na SDS-PAGE. |
| Buffer | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300, pH7.4 |
| Ububiko | Ubike mubihe bidasanzwe kuri -20 ℃ kugeza -80 ℃ umaze kwakira. Saba kugabanya poroteyine muke kugirango ubike neza. |
Kugereranya Kurushanwa
| Bioantibody | Indwara Yasuzumwe | Igiteranyo | |
| Ibyiza | Ibibi | ||
| Ibyiza | 35 | 0 | 35 |
| Ibibi | 1 | 87 | 88 |
| Igiteranyo | 36 | 87 | 123 |
| Umwihariko | 100% | ||
| Ibyiyumvo | 97% | ||
Tegeka amakuru
| izina RY'IGICURUZWA | Injangwe.Oya | Indangamuntu ya Clone |
| IGFBP-1 | AB0028-1 | 4H6-2 |
| AB0028-2 | 4C2-3 | |
| AB0028-3 | 2H11-1 | |
| AB0028-4 | 3G12-11 |
Icyitonderwa: Bioantibody irashobora kugereranya ingano kubyo ukeneye.
Imirongo
1.Rutanen EM.Gukura kwa insuline kumera gukura poroteyine 1: US 1996.
2.Harman, S, Mitchell, n'abandi.Urwego rwa Serumu ya Insuline-Nkura yo Gukura I (IGF-I), IGF-II, IGF-Binding Protein-3, na Antigen yihariye ya Prostate nk'abahanuzi ba Kanseri ya Prostate Clinique [J].Ikinyamakuru cya Clinical Endocrinology & Metabolism, 2000.
