Kurwanya abantu TIMP1 Antibody, Imbeba Monoclonal

Amakuru rusange
TIMP metallopeptidase inhibitor 1, izwi kandi nka TIMP-1 / TIMP1, Inhibitor ya Collagenase 16C8 fibroblast Erythroid-potentiating, TPA-S1TPA iterwa na proteinTissue inhibitor ya metalloproteinase 1, ni inzitizi karemano ya matrix metalloproteinase (MMPs), itsinda rya MMPs; agira uruhare mu gutesha agaciro matrix idasanzwe.TIMP-1 / TIMP1 iboneka mu nyama no mu ngingo zikuze.Urwego rwo hejuru ruboneka mu magufa, ibihaha, intanga ngore na nyababyeyi.Ibigo hamwe na metalloproteinase kandi ntigikora kuburyo budasubirwaho muguhuza cofactor ya catalitiki ya zinc.TIMP-1 / TIMP1 ihuza erythropoiesis muri vitro;ariko, bitandukanye na IL-3, ni ubwoko bwihariye, butera gukura no gutandukanya gusa abantu na murine erythroid progenitor.Usibye uruhare rwayo rwo kubuza kurwanya MMP nyinshi zizwi, poroteyine irashobora guteza imbere ikwirakwizwa ry'uturemangingo mu bwoko butandukanye bw'utugingo ngengabuzima, kandi ishobora no kugira imikorere irwanya apoptotique.Kwandukura iyi poroteyine igizwe na gene ntibishoboka cyane mugusubiza cytokine na hormone nyinshi.Byongeye kandi, imvugo ya bamwe ariko siko chromosomes idakora yose yerekana ko uku kudakora gene ari polymorphic kubagore babantu.Iyi kodegisi ya gene iri muri intron 6 ya synapsin I gene kandi yandukuwe muburyo bunyuranye.Ibigo hamwe na metalloproteinase kandi ntigikora kuburyo budasubirwaho muguhuza cofactor ya catalitiki ya zinc.TIMP-1 / TIMP1 Azwiho gukora kuri MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 na MMP-16.