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Anti- PIVKA -II Antibody, Imbeba Monoclonal

Ibisobanuro bigufi:

Kwezwa Poroteyine A / G inkingi Isotype IgG1 kappa
Ubwoko bwakiriwe Imbeba Ubwoko bwa Antigen Umuntu
Gusaba Immunochromatography(IC) /Chemiluminescent Immunoassay(CLIA)

Ibicuruzwa birambuye

Ibicuruzwa

Amakuru rusange

Poroteyine Yatewe na Vitamine K Kubura cyangwa Antagonist-II (PIVKA-II), izwi kandi nka Des-γ-carboxy-prothrombine (DCP), ni uburyo budasanzwe bwa prothrombine.Mubisanzwe, prothrombine 10 isigara ya glutamic aside (Glu) murwego rwa γ-carboxyglutamic aside (Gla) kumwanya wa 6, 7, 14, 16, 19, 20,25, 26, 29 na 32 ni γ-karubasi ya Gla na vitamine. -K biterwa na gl- glutamyl carboxylase mu mwijima hanyuma ikinjira muri plasma.Ku barwayi barwaye kanseri ya hepatocellular (HCC), car-carboxylation ya prothrombine irabangamiwe ku buryo PIVKA-II iba mu mwanya wa prothrombine.PIVKA-II ifatwa nkaho ari biomarker ikora neza kuri HCC.

Ibyiza

Icyifuzo CLIA (Gufata-Kumenya):

1E5 ~ 1D6

1E5 ~ 1E6

Isuku > 95%, bigenwa na SDS-PAGE
Buffer 20 mM PB, 150 mM NaCl, 0.1% Proclin 300, pH7.4
Ububiko Ubike mubihe bidasanzwe kuri -20 ℃ kugeza -80 ℃ umaze kwakira.Kububiko bwigihe kirekire, nyamuneka aliquot uyibike.Irinde gukonjesha inshuro nyinshi.

Isesengura ryo kugereranya

ibicuruzwa
ibicuruzwa

Tegeka amakuru

izina RY'IGICURUZWA Injangwe.Oya Indangamuntu ya Clone
PIVKA- AB0009-1 1F4
AB0009-2 1E5
AB0009-3 1D6
AB0009-4 1E6

Icyitonderwa: Bioantibody irashobora kugereranya ingano kubyo ukeneye.

Imirongo

1.Matsueda K, Yamamoto H, Yoshida Y, n'abandi.Kanseri ya Hepatoide ya pancreas itanga proteyine iterwa na vitamine K idahari cyangwa antagonist II (PIVKA-II) na α-fetoprotein (AFP) [J].Ikinyamakuru cya Gastroenterology, 2006, 41 (10): 1011-1019.

2.Viggiani, Valentina, Palombi, 等.Poroteyine ziterwa na vitamine K idahari cyangwa antagonist-II (PIVKA-II) yiyongereye cyane ku barwayi ba kanseri ya hepatocellular yo mu Butaliyani. [J].Ikinyamakuru cya Scandinaviya cya Gastroenterology, 2016.

3.Simundic AM.Ibyifuzo bifatika byo gusesengura imibare no kwerekana amakuru mu kinyamakuru cya Biochemia Medica [J].Biochemia Medica, 2012, 22 (1).

4.Tartaglione S, Pecorella I, Zarrillo SR, n'abandi.Poroteyine Yatewe na Vitamine K Kubura II (PIVKA-II) nka biomarker ishobora kuba kanseri ya kanseri yandura: ubushakashatsi bwikigereranyo [J].Biochemia Medica, 2019, 29 (2).


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