Kurwanya abantu IL6, Imbeba Monoclonal

Amakuru rusange
Interleukin-6 (IL-6) ni cytokine ikora cyane α-helical cytokine igenga imikurire yimikorere no gutandukanya ingirangingo zitandukanye, izwi cyane cyane uruhare rwayo mugukingira indwara no gukira ibyiciro bikaze.Poroteyine ya IL-6 isohorwa nubwoko butandukanye bwingirabuzimafatizo zirimo T selile na macrophage nka fosifori na molekile ya glycosilated.Ikora ibikorwa ikoresheje reseptor yayo ya heterodimeric igizwe na IL-6R idafite domaine ya tyrosine / kinase ikanahuza IL-6 hamwe n’ubucuti buke, kandi ikagaragaza hose glycoproteine ​​130 (gp130) ihuza IL-6.IL-6R igoye cyane kandi yegeranye bityo ikanatanga ibimenyetso.IL-6 igira kandi uruhare mu kuvura indwara ya hematopoiesis, metabolism yo mu magufa, no gutera kanseri, kandi byasobanuwe nk'uruhare rukomeye mu kuyobora inzibacyuho kuva mu kavukire kugera ku budahangarwa bw'umubiri.