Kurwanya abantu CHI3L1 Antibody, Monoclonal yumuntu

Amakuru rusange
Chitinase-3 isa na poroteyine 1 (CHI3L1) ni heparine ihuza glycoproteine ​​isohoka, imvugo yayo ifitanye isano no kwimuka kwimitsi yimitsi yimitsi.CHI3L1 igaragarira murwego rwo hejuru mumico ya VSMC ya postconfluent no kurwego rwo hasi mumico ikwirakwira.CHI3L1 ni inyigisho zabujijwe, inyigisho za chitin zihuza kandi akaba n'umwe mu bagize umuryango wa hydrocase ya glycosyl 18. Bitandukanye n’ibindi bimenyetso byinshi bya monocyto / macrophage, imvugo yabyo ntikiboneka muri monocytes kandi ikomeye iterwa mugihe cyanyuma cyo gutandukanya macrophage yabantu.Urwego rwo hejuru rwa CHI3L1 rufitanye isano n’imivurungano yerekana ubwiyongere bw’imitsi ihindagurika, nka rheum atoid, arthritis, osteoarthritis, scleroderma, na cirrhose yumwijima, ariko ikorerwa muri karitsiye itangwa nabaterankunga bashaje cyangwa abarwayi bafite osteoarthritis.CHI3L1 igaragarira mu buryo budasanzwe muri hippocampus y’amasomo afite sikizofreniya kandi irashobora kugira uruhare mu gusubiza mu ngirabuzimafatizo ku bintu bitandukanye by’ibidukikije bivugwa ko byongera ibyago byo kurwara sikizofreniya.