Helicobacter pylori (HP) ni bagiteri iba mu gifu kandi ikomera ku mucyo wo mu gifu no mu myanya ndangagitsina, bigatera uburibwe.Indwara ya HP ni imwe mu ndwara ziterwa na bagiteri, zanduza abantu babarirwa muri za miriyari ku isi.Nizo mpamvu nyamukuru zitera ibisebe na gastrite (gutwika igifu).

Kwandura kwinshi mu bana no guteranya imiryango nibyo biranga ubwandu bwa HP, kandi kwanduza umuryango bishobora kuba inzira nyamukuru kwandura HP ni ikintu gikomeye gitera indwara ya gastrite idakira, ibisebe byitwa peptic, gastric mucosa ifitanye isano na lymphhoide tissue (MALT) lymphoma, na kanseri yo mu gifu.Mu 1994, Ishami ry'Umuryango w'Abibumbye ryita ku Buzima / Ikigo mpuzamahanga gishinzwe ubushakashatsi kuri Kanseri (OMS / IARC) cyagennye Helicobacter pylori nk'icyiciro cya mbere cya kanseri

Gastric mucosa - ibirwanisho byumubiri wigifu

Mubihe bisanzwe, urukuta rwigifu rufite urukurikirane rwuburyo bwiza bwo kwikingira (gusohora aside gastric na protease, kurinda ibibyimba bitangirika kandi bitangirika, imyitozo isanzwe, nibindi), bishobora kurwanya igitero cyibinyabuzima ibihumbi. byinjira mu kanwa.

HP ifite flagella yigenga hamwe nuburyo bwihariye bwo guhindagurika, ntabwo bigira uruhare runini mugihe cyo gukoloniza kwa bagiteri, ariko kandi birashobora guhinduka kandi bigakora imiterere yo kwikingira birinda ibidukikije.Muri icyo gihe, Helicobacter pylori irashobora kubyara uburozi butandukanye, bugena ko Helicobacter pylori ishobora kunyura mu gice cy umutobe wigifu ukoresheje imbaraga zayo kandi ikarwanya aside gastrici nibindi bintu bitameze neza, bigahinduka mikorobe yonyine ishobora kubaho mu gifu cyumuntu .

Indwara ya Helicobacter pylori

1. Dynamic

Ubushakashatsi bwerekanye ko Helicobacter pylori ifite ubushobozi bukomeye bwo kwimuka ahantu hatuje, kandi flagella irakenewe kugirango bagiteri zoga zijye kumitsi irinda hejuru ya mucosa gastric.

2. Endotoxine ifitanye isano na poroteyine A (CagA) n'uburozi bwa vacuolar (VacA)

Cytotoxine ifitanye isano na gene A (CagA) proteine ​​isohorwa na HP irashobora gukurura igisubizo cyaho.Indwara ya CagA-nziza ya Helicobacter pylori irashobora kandi kongera cyane ibyago byo kurwara gastrite ya atrophike, metaplasia yo munda na kanseri yo mu gifu.

Vacuolating cytotoxine A (VacA) nikindi kintu cyingenzi gitera indwara ya Helicobacter pylori, ishobora kwinjira mitochondriya kugirango igenzure imikorere ya selile.

3. Flagellin

Poroteyine ebyiri za flagellin, FlaA na FlaB, zigize ibintu byingenzi bigize ibendera rya flagellar.Impinduka muri flagellin glycosylation igira ingaruka kumikorere.Iyo urwego rwa FlaA protein glycosylation rwiyongereye, ubushobozi bwo kwimuka hamwe nubukoroni bwumutwaro bwiyongereye.

4. Kureka

Urease itanga NH3 na CO2 ikoresheje hydrolyzing urea, itesha aside gastricike kandi ikazamura pH ya selile ikikije.Byongeye kandi, urease igira uruhare mubisubizo byokongeza kandi igatera kwizirika muguhuza na reseptor ya CD74 kuri selile epithelia selile.

5. Shyushya poroteyine HSP60 / GroEL

Helicobacter pylori ikurura urukurikirane rwa poroteyine zabitswe cyane, muri zo zifatanije na Hsp60 hamwe na urease muri E. coli byongera cyane ibikorwa bya urease, bigatuma virusi itera kandi ikabaho mu cyicaro cy’ibidukikije cyangiza igifu cy’umuntu.

6. Intungamubiri zifitanye isano na poroteyine 2 homologi FliD

FliD ni poroteyine yubatswe irinda isonga rya flagella kandi irashobora gushiramo inshuro nyinshi flagellin kugirango ikure ibendera.FliD ikoreshwa kandi nka molekile ya adhesion, ikamenya molekile ya glycosaminoglycan ya selile yakira.Mu banduye banduye, antibodiyide zirwanya flid ni ibimenyetso byanduye kandi birashobora gukoreshwa mugupima serologiya.

Uburyo bwo Kwipimisha:

1. Ikizamini cy'intebe: Ikizamini cya antigen ya stool ni ikizamini kidatera H. pylori.Igikorwa gifite umutekano, cyoroshye kandi cyihuse, kandi ntigisaba ubuyobozi bwo munwa bwa reagent.

2. Kumenya antibody ya serumu: Iyo Helicobacter pylori yanduye ibaye mumubiri, umubiri wumuntu uzaba ufite antibodiyite zirwanya Helicobacter pylori mumaraso kubera ubudahangarwa bw'umubiri.Mugushushanya amaraso kugirango urebe niba antibodiyite ya Helicobacter pylori yibanze, irashobora kwerekana niba mumubiri harimo Helicobacter pylori.kwandura bagiteri.

3. Ikizamini cyo guhumeka: Ubu ni uburyo bwo kugenzura buzwi cyane muri iki gihe.Urea yo mu kanwa irimo 13C cyangwa 14C, hamwe no guhumeka bipima ubunini bwa dioxyde de carbone irimo 13C cyangwa 14C nyuma yigihe runaka, kuko niba hari Helicobacter pylori, urea izamenyekana na urea yihariye.Enzymes zicamo ammonia na dioxyde de carbone, isohoka mu bihaha ikoresheje amaraso.

4. Endoskopi: ituma ukurikiranira hafi ibintu bya mucosal gastrica nko gutukura, kubyimba, guhinduka kwa nodular, nibindi.;endoskopi ntabwo ibereye abarwayi bafite ibibazo bikomeye cyangwa imiti igabanya ubukana hamwe nigiciro cyinyongera (anesthesia, imbaraga)).

Bioantibody ibicuruzwa bijyanye na H.pyloriibyifuzo:

H. Pylori Antigen Ikizamini Cyihuta (Chromatography)

H. Pylori Antibody Yihuta Yikizamini (Chromatografiya)